Disciplina | Tópicos Especiais em Biotecnologia: Entendendo o Cenário Atual da Sepse e Málária Através de suas Patofisiologias, Mmodelos Experimentais e Identificação de Novos Fármacos |
Código | BTC-014.02 |
Tipo | Optativa |
Nº de créditos | 2 |
Carga Horária | 30 Teorica / 0 Prática |
Período | 02/2017 |
Nº de Vagas | 15 |
Turma | 01-MA |
Período das Aulas | 22/11/2017 a 24/11/2017 |
Observações | horário integral. |
Professores | |
Horários | |
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Ementa | |
Modelos experimentais de sepse. Patofisiologia da sepse. Prospecção de fármacos. Patofisiologia da malária. Modelos experimentais e utilização na prospecção de fármacos. | |
Bibliográfia | |
Brunetti et al., 2017. Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs. Curr Top Med Chem. 17(5):613-619. Engwerda et al. 2005. Experimental models of cerebral malaria. Curr Top Microbiol Immunol. 297:103-43. Good MF et al., 2015. Humanized Mouse Models to Study Cell-Mediated Immune Responses to Liver-Stage Malaria Vaccines. Trends Parasitol. 31(11):583-94. Hu et al., 2012. When host defense goes awry: Modeling sepsis-induced immunosuppression. Drug Discov Today Dis Models. 9(1):e33-e38. Jeger et al., 2016. Analgesia in clinically relevant rodent models of sepsis. Lab Anim. 50(6):418-426. Lamb et al. 2006. Insights into the immunopathogenesis of malaria using mouse models. Expert Rev Mol Med. 8(6):1-22. Neres et al., 2008. Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women. PLoS One. 3(2):e1608. Noulin F. 2016. Malaria modeling: In vitro stem cells vs in vivo models. World J Stem Cells. 8(3):88-100. Rasid and Cavaillon. 2016. Recent developments in severe sepsis research: from bench to bedside and back. Future Microbiol. 11(2):293-314. Rocha e Silva, M. 2016. Cardiovascular Effects of Shock and Trauma in Experimental Models. A Review.Braz J Cardiovasc Surg. 31(1):45-51. Starr and Saito, 2014. Sepsis in old age: review of human and animal studies. Aging Dis. 5(2):126-36. Stortz et al., 2017. Murine Models of Sepsis and Trauma: Can We Bridge the Gap? ILAR J. 21:1-16. van der Poll, T. 2012. Preclinical sepsis models. Surg Infect (Larchmt). 13(5):287-92. Volpe et al., 2015. The brain at risk: the sepsis syndrome and lessons from preclinical experiments. Immunol Res. 63(1-3):70-4. Zanotti-Cavazzoni and Goldfarb., 2009. Animal models of sepsis. Crit Care Clin. 25(4):703-19. |