Bionorte em Números
Artigo Publicado
| Ano do artigo | 2019 |
| Descrições/informações adicionais | The gastroprotective effect of a turmeric acetone extract (TAE) (Curcuma longa L. [Zingiberaceae]) was evaluated and compared against its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites? ratio in the extract on the synergistic effect, different mixtures were evaluated. An ethanol-induced gastric injury model was used to evaluate the gastroprotection activity in Wistar rats. The pharmacologic interaction analysis was performed using the Combination Index (CI)-Isobologram Equation method. The CI calculated at 0.5 of affected fraction (fa) for the TAE indicated a synergistic interaction between its components. However, when the proportion of curcuminoids changed from 3.7:1:10 in TAE to a 1:1:1 ratio, the CI implied an antagonistic effect. The binary combinations of curcuminoids (1:1) also showed an antagonistic interaction. The results of this work suggest that the proportion of curcuminoids in the TAE is crucial for the gastroprotective effect against ethanol-induced damage. |
| Descrições/informações adicionais(EN) | The gastroprotective effect of a turmeric acetone extract (TAE) (Curcuma longa L. [Zingiberaceae]) was evaluated and compared against its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites? ratio in the extract on the synergistic effect, different mixtures were evaluated. An ethanol-induced gastric injury model was used to evaluate the gastroprotection activity in Wistar rats. The pharmacologic interaction analysis was performed using the Combination Index (CI)-Isobologram Equation method. The CI calculated at 0.5 of affected fraction (fa) for the TAE indicated a synergistic interaction between its components. However, when the proportion of curcuminoids changed from 3.7:1:10 in TAE to a 1:1:1 ratio, the CI implied an antagonistic effect. The binary combinations of curcuminoids (1:1) also showed an antagonistic interaction. The results of this work suggest that the proportion of curcuminoids in the TAE is crucial for the gastroprotective effect against ethanol-induced damage. |
| Divulgação científica | NAO |
| DOI | 10.1080/14786419.2019.1644504 |
| Homepage do trabalho | [doi:10.1080/14786419.2019.1644504] |
| Idioma | Inglês |
| ISSN | 14786419 |
| Meio de divulgação | MEIO_DIGITAL |
| Natureza | COMPLETO |
| Página final | 6 |
| Página inicial | 1 |
| Relevânica | NAO |
| Sequencia da produção | 942 |
| Série | 3 |
| Título do artigo | Effect of the proportion of curcuminoids on the gastroprotective action of L. in rats |
| Título do artigo(EN) | Effect of the proportion of curcuminoids on the gastroprotective action of L. in rats |
| Título do periódico ou revista | NATURAL PRODUCT RESEARCH |
| Volume | 33 |
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